Pfizer Inc. · PFE · FY2024 Q4 · Calendar Q1 2025

Pfizer Maintains Guidance While Advancing Oncology and Vaccine Pipeline

Pfizer's maintained guidance, oncology and vaccine pipeline progress, cost savings and commercial execution support a constructive operating case; the evidence is tempered by pricing reform, regulatory, competitive and COVID-19 demand risks.

Reported Before market openNYSEHealthcare $171.16B market cap
80quality score

Earnings scorecard

Reported versus consensus
Reported EPS — Consensus $0.48
EPS surprise — Reported versus consensus
Reported revenue — Consensus $17.28B
Revenue surprise — Reported versus consensus

Market reaction

prior-close to event-session close
Stock move -1.3% Event window
SPY move +0.7% Same window
Abnormal move -1.9% Stock minus SPY
Volume 1.9× Versus trailing sessions
Subsequent drift +0.3% Up to 20 sessions
PFESPY benchmark

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Transcript intelligence

What changed

Compared with the prior quarter, management moved from raised full-year 2024 guidance to maintained 2025 guidance, while sharpening focus on Seagen-enabled oncology, vaccine pipeline expansion, cost realignment, deleveraging and AI-enabled commercial execution.

Guidance delta

Management maintained 2025 guidance at $61-$64 billion of revenue and $2.80-$3.00 of adjusted EPS.

Key takeaways

  • Management described 2024 revenue of $63.6 billion and adjusted EPS of $3.11, with full-year margin expansion to 74%.
  • The company emphasized oncology pipeline milestones, vaccine expansion and AI-enabled commercial execution.
  • Cost realignment targets $4.5 billion of net savings by 2025, alongside a goal of 3.25x gross leverage by year-end 2025.
  • Management outlined Phase 3 work for PCV-25, a preclinical PCV-30 program and continued development of metabolic candidates.

Management priorities

  • Advance oncology pipeline milestones and regulatory decisions.
  • Launch Phase 3 studies for PCV-25 and continue the preclinical PCV-30 program.
  • Deliver the cost-savings program and pursue deleveraging.
  • Expand AI-enabled commercial platforms and global field resource deployment.
  • Evaluate business-development opportunities and monetize the remaining Haleon stake.

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Earnings History

Estimate Beat Miss Match
PFE EPS earnings history estimate and actual scatter chart 9 reported fiscal quarters and 3 future estimate-only quarters. Q1 '24 estimate $0.52 Q1 '24 actual $0.82, beat Q2 '24 estimate $0.46 Q2 '24 actual $0.60, beat Q3 '24 estimate $0.61 Q3 '24 actual $1.06, beat Q2 '25 estimate $0.58 Q2 '25 actual $0.78, beat Q3 '25 estimate $0.63 Q3 '25 actual $0.87, beat Q4 '25 estimate $0.57 Q4 '25 actual $0.66, beat Q1 '26 estimate $0.72 Q1 '26 actual $0.75, beat Q2 '26 estimate $0.68 Q2 '26 actual $0.77, beat Q3 '26 estimate $0.73 Q4 '26 estimate $0.70 Q1 '27 estimate $0.66
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Analyst Consensus ?

ConsensusHold39 ratings
Bullish1538.4%
Neutral2359.0%
Bearish12.6%

1 unmapped firm rating excluded from the percentages.

Analyst 52W Price Targets

$30.03Current
$20Low
$39.14Average
$70High

Latest persisted target per named analyst; persisted current price from FN2's market snapshot as of Oct 25, 2026. Not an FN2 forecast.

Firm-level rating actions

FMP grade actions identify the grading firm, not a named analyst.

FirmRatingPrior ratingActionDate
JP Morgan Neutral NeutralMaintainOct 9, 2026
Cantor Fitzgerald Neutral NeutralMaintainOct 8, 2026
Scotiabank Sector Outperform Sector OutperformMaintainOct 6, 2026
HSBC Hold HoldMaintainSep 10, 2026
Guggenheim Buy BuyMaintainAug 7, 2026
Show 35 more rating actions

Named analyst price targets

Upside is calculated against the persisted current price $30.03. FMP does not supply a rating on these named-analyst rows.

FirmAnalyst52W targetPrice when postedUpsideDate
Cantor FitzgeraldCarter Gould$28$28 -6.8%Oct 8, 2026
ScotiabankAnalyst unavailable$33$27.3 +9.9%Oct 6, 2026
HSBCAnalyst unavailable$30$27.78 -0.1%Sep 10, 2026
GuggenheimAnalyst unavailable$31$26.2 +3.2%Aug 7, 2026
HSBCAnalyst unavailable$28$24.32 -6.8%Jul 6, 2026
See 59 more

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Company context

Snapshot as of publication

Pfizer Inc. is a global biopharmaceutical leader engaged in the research, development, production, marketing, and distribution of a wide array of medicinal and vaccine products worldwide. Its comprehensive portfolio addresses diverse therapeutic areas, including cardiovascular health and women's health, featuring key brands such as the Premarin family and Eliquis. The company also offers advanced biologics, small molecule drugs, immunotherapies, and biosimilars for various conditions, exemplified by Ibrance, Xtandi, and Retacrit. Furthermore, Pfizer provides sterile injectables, anti-infective agents, and a significant oral treatment for COVID-19, including Paxlovid.…

Historical context

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Sources

  1. Earnings call transcript and parsed analysis · 2026-05-11T10:29:34.698584+00:00
  2. FN2 earnings calendar · 2025-01-21T00:01:13.267231+00:00
  3. Polygon adjusted daily market bars · 2026-10-25T04:00:45.317920+00:00
  4. Financial Modeling Prep analyst price-target consensus and quote snapshot · 2026-10-25T04:00:45.315714+00:00

Methodology

Reported and consensus figures come from FN2's earnings event records. Market reaction and volume are calculated from daily adjusted bars around the event; abnormal move subtracts the SPY move over the same window.

Analyst target low, average, and high values are derived at request time from each named analyst's latest persisted FMP target. The current-price marker comes from FN2's persisted market snapshot. They are sell-side estimates, not an FN2 valuation or recommendation.

Transcript intelligence is a structured synthesis of the current and prior earnings-call analyses. Missing values stay missing and are never estimated.

By FN2 Research · Updated · As of 2026-10-25. For educational purposes only; not investment advice.