Merck & Co., Inc. · MRK · FY2025 Q4 · Calendar Q1 2026

Merck holds 2026 outlook as launches and pipeline offset patent risk

The supplied analysis supports a measured growth case: launches, pipeline progress, animal-health expansion and acquisitions provide growth avenues, while pricing pressure, generic competition and Keytruda's intellectual-property runway constrain confidence.

Reported Before market openNYSEHealthcare $367.26B market cap
100quality score

Earnings scorecard

Reported versus consensus
Reported EPS $2.04 Consensus $2.01
EPS surprise +1.5% Reported versus consensus
Reported revenue $16.40B Consensus $16.20B
Revenue surprise +1.2% Reported versus consensus

Market reaction

prior-close to event-session close
Stock move +2.2% Event window
SPY move -0.8% Same window
Abnormal move +3.0% Stock minus SPY
Volume 2.0× Versus trailing sessions
Subsequent drift +3.8% Up to 20 sessions
MRKSPY benchmark

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Transcript intelligence

What changed

The current analysis adds Sidera Therapeutics to the acquisition set, emphasizes 2026 Phase III readouts and launch ramp-up, and retains a confident tone with guidance maintained.

Guidance delta

Maintained. The supplied analysis cites 2026 revenue guidance of $65.5-$67 billion and EPS guidance of $5.00-$5.15, incorporating a $9 billion one-time Sidera charge.

Key takeaways

  • Q4 revenue growth was modest but steady, with Keytruda remaining a core contributor.
  • New launches and pipeline readouts are central to the growth case, including Keytruda QLEX, O2Ver, enlicitide, MK1406, MK3000 and sac TMT.
  • The main counterweights are upcoming generic competition, U.S. IRA pricing, Keytruda exclusivity risk and acquisition execution.

Management priorities

  • Ramp Keytruda QLEX and O2Ver.
  • Advance 2026 Phase III programs across HIV, ophthalmology, oncology and small-cell lung cancer.
  • Continue business development and expand animal-health products and market penetration.

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Earnings History

Estimate Beat Miss Match
MRK REVENUE earnings history estimate and actual scatter chart 9 reported fiscal quarters and 3 future estimate-only quarters. Q1 '24 estimate $15B Q1 '24 actual $16B, beat Q2 '24 estimate $16B Q2 '24 actual $16B, beat Q3 '24 estimate $16B Q3 '24 actual $17B, beat Q2 '25 estimate $16B Q2 '25 actual $16B, miss Q3 '25 estimate $17B Q3 '25 actual $17B, beat Q4 '25 estimate $16B Q4 '25 actual $16B, beat Q1 '26 estimate $16B Q1 '26 actual $16B, beat Q2 '26 estimate $16B Q2 '26 actual $17B, beat Q3 '26 estimate $17B Q4 '26 estimate $17B Q1 '27 estimate $17B
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Analyst Consensus ?

ConsensusBuy38 ratings
Bullish2668.4%
Neutral1129.0%
Bearish12.6%

Analyst 52W Price Targets

$149.28Current
$80Low
$136.49Average
$180High

Latest persisted target per named analyst; persisted current price from FN2's market snapshot as of Sep 29, 2026. Not an FN2 forecast.

Firm-level rating actions

FMP grade actions identify the grading firm, not a named analyst.

FirmRatingPrior ratingActionDate
HSBC Buy BuyMaintainSep 10, 2026
Leerink Partners Outperform OutperformMaintainSep 9, 2026
Guggenheim Buy BuyMaintainSep 8, 2026
Wells Fargo Overweight OverweightMaintainSep 4, 2026
Wolfe Research Outperform OutperformMaintainAug 25, 2026
Show 33 more rating actions

Named analyst price targets

Upside is calculated against the persisted current price $149.28. FMP does not supply a rating on these named-analyst rows.

FirmAnalyst52W targetPrice when postedUpsideDate
Berenberg BankLuisa Hector$137$144.71 -8.2%Sep 11, 2026
HSBCAnalyst unavailable$172$147.6 +15.2%Sep 10, 2026
Leerink PartnersAnalyst unavailable$161$148.49 +7.9%Sep 9, 2026
GuggenheimVamil Divan$170$150.34 +13.9%Sep 8, 2026
Wells FargoAnalyst unavailable$170$152.34 +13.9%Sep 4, 2026
See 84 more

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Company context

Snapshot as of publication

Merck & Co., Inc. is a global healthcare leader with operations spanning two core divisions: Pharmaceuticals and Animal Health. The Pharmaceutical segment is dedicated to human health, offering a broad spectrum of medicinal products. These cover crucial therapeutic areas such as oncology, acute hospital care, immunology, neuroscience, virology, cardiovascular conditions, and diabetes. This division also develops vital preventive vaccines for pediatric, adolescent, and adult populations. Meanwhile, the Animal Health segment focuses on the research, development, manufacturing, and marketing of veterinary medications, vaccines, and comprehensive health management solutions for animals. This division further provides innovative digital products designed for animal identification, traceability, and continuous monitoring.…

Historical context

All MRK earnings

Healthcare peers this season

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MDT Medtronic plc FY2027 Q1 · Calendar Q3 2026 +4.3% +1.5% Medtronic raises FY27 outlook as growth broadens across platforms

Latest beats and misses

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Sources

  1. Earnings call transcript and parsed analysis · 2026-05-11T10:29:34.698584+00:00
  2. FN2 earnings calendar · 2026-07-26T00:37:12.209961+00:00
  3. Polygon adjusted daily market bars · 2026-09-29T21:31:00.642443+00:00
  4. Financial Modeling Prep analyst price-target consensus and quote snapshot · 2026-09-29T21:31:00.638709+00:00

Methodology

Reported and consensus figures come from FN2's earnings event records. Market reaction and volume are calculated from daily adjusted bars around the event; abnormal move subtracts the SPY move over the same window.

Analyst target low, average, and high values are derived at request time from each named analyst's latest persisted FMP target. The current-price marker comes from FN2's persisted market snapshot. They are sell-side estimates, not an FN2 valuation or recommendation.

Transcript intelligence is a structured synthesis of the current and prior earnings-call analyses. Missing values stay missing and are never estimated.

By FN2 Research · Updated · As of 2026-09-29. For educational purposes only; not investment advice.