Eli Lilly and Company · LLY · FY2025 Q4 · Calendar Q1 2026

Lilly pairs strong incretin growth with major 2026 execution demands

The supplied analysis supports the view that strong incretin demand and earnings growth can support Lilly's trajectory over the next year. The key test is whether volume growth and new launches offset pricing pressure, reimbursement constraints, competition, and execution risk.

Reported Before market openNYSEHealthcare $1117.00B market cap
100quality score

Earnings scorecard

Reported versus consensus
Reported EPS $7.54 Consensus $6.91
EPS surprise +9.1% Reported versus consensus
Reported revenue $19.29B Consensus $17.94B
Revenue surprise +7.5% Reported versus consensus

Market reaction

prior-close to event-session close
Stock move +10.3% Event window
SPY move -0.5% Same window
Abnormal move +10.8% Stock minus SPY
Volume 2.3× Versus trailing sessions
Subsequent drift -11.2% Up to 20 sessions
LLYSPY benchmark

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Transcript intelligence

What changed

The current analysis adds a 2026 outlook centered on continued Mounjaro and Zepbound expansion, a potential Orforglipron launch, broader access initiatives, manufacturing investment, and an NVIDIA AI collaboration. Compared with the prior analysis, the focus shifts from raising near-term guidance and preparing the pipeline toward executing a larger-scale 2026 growth plan.

Guidance delta

Management's supplied analysis describes 2026 guidance of $80-$83 billion in revenue and $33.50-$35 in EPS, following strong 2025 growth. The direction is raised versus the prior-quarter analysis.

Key takeaways

  • Mounjaro and Zepbound remain the central growth drivers, supported by broader access and international rollout.
  • The supplied analysis points to 2026 revenue guidance of $80-$83 billion and EPS guidance of $33.50-$35.
  • Orforglipron is positioned as a major next step in oral obesity treatment, but regulatory and launch timing matter.
  • Manufacturing expansion and the NVIDIA AI collaboration increase the investment and execution agenda.
  • Lower realized prices, reimbursement limits, competition, and launch execution are the main counterweights.

Management priorities

  • Expand Mounjaro and Zepbound access and international adoption.
  • Advance Orforglipron and the broader oral GLP-1 pipeline.
  • Build manufacturing capacity in the US and Europe.
  • Use AI collaboration and additional clinical readouts to support pipeline productivity.
  • Execute access agreements and new product launches.

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Earnings History

Estimate Beat Miss Match
LLY EPS earnings history estimate and actual scatter chart 9 reported fiscal quarters and 3 future estimate-only quarters. Q1 '24 estimate $2.46 Q1 '24 actual $2.58, beat Q2 '24 estimate $2.60 Q2 '24 actual $3.92, beat Q3 '24 estimate $1.47 Q3 '24 actual $1.18, miss Q2 '25 estimate $5.60 Q2 '25 actual $6.31, beat Q3 '25 estimate $5.69 Q3 '25 actual $7.02, beat Q4 '25 estimate $6.91 Q4 '25 actual $7.54, beat Q1 '26 estimate $6.97 Q1 '26 actual $8.55, beat Q2 '26 estimate $6.40 Q2 '26 actual $8.38, beat Q3 '26 estimate $9.92 Q4 '26 estimate $9.93 Q1 '27 estimate $9.98
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Analyst Consensus ?

ConsensusBuy45 ratings
Bullish3373.3%
Neutral920.0%
Bearish36.7%

Analyst 52W Price Targets

$1,184.63Previous close
$265Low
$985.42Average
$1,500High

Latest persisted target per named analyst; persisted previous close from FN2's market snapshot as of Sep 30, 2026. Not an FN2 forecast.

Firm-level rating actions

FMP grade actions identify the grading firm, not a named analyst.

FirmRatingPrior ratingActionDate
JP Morgan Overweight OverweightMaintainSep 28, 2026
TD Cowen Buy BuyMaintainSep 22, 2026
Guggenheim Buy BuyMaintainSep 18, 2026
HSBC Reduce ReduceMaintainSep 10, 2026
Truist Securities Buy BuyMaintainAug 7, 2026
Show 40 more rating actions

Named analyst price targets

Upside is calculated against the persisted previous close $1,184.63. FMP does not supply a rating on these named-analyst rows.

FirmAnalyst52W targetPrice when postedUpsideDate
GuggenheimSeamus Fernandez$1,284$1,152.13 +8.4%Sep 18, 2026
Berenberg BankKerry Holford$1,400$1,137.75 +18.2%Sep 15, 2026
HSBCAnalyst unavailable$940$1,124.16 -20.7%Sep 10, 2026
UBSAnalyst unavailable$1,376$1,177.33 +16.2%Aug 7, 2026
Cantor FitzgeraldAnalyst unavailable$1,410$1,181 +19.0%Aug 6, 2026
See 126 more

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Company context

Snapshot as of publication

Eli Lilly and Company is a prominent global pharmaceutical firm dedicated to the research, development, and commercialization of human medicines across the world. Its therapeutic offerings include a comprehensive suite of diabetes medications. This encompasses various insulin formulations like Basaglar, the Humalog family (e.g., Mix 75/25, U-100, U-200, Mix 50/50), insulin lispro products (including protamine and mix 75/25), and the Humulin line (e.g., 70/30, N, R, U-500). Furthermore, Eli Lilly provides specialized treatments for type 2 diabetes, such as Jardiance, Trajenta, and Trulicity. In oncology, Eli Lilly offers a robust portfolio targeting various cancers. These include Alimta for non-small cell lung cancer (NSCLC) and malignant pleural mesothelioma; Cyramza, indicated for metastatic gastric cancer, gastro-esophageal junction adenocarcinoma, metastatic NSCLC, metastatic colorectal cancer, and hepatocellular carcinoma; Erbitux for colorectal and various head and neck cancers; Retevmo, used in metastatic NSCLC, medullary…

Historical context

All LLY earnings

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Latest beats and misses

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Sources

  1. Earnings call transcript and parsed analysis · 2026-05-11T10:29:34.698584+00:00
  2. FN2 earnings calendar · 2026-07-26T00:36:15.940040+00:00
  3. Polygon adjusted daily market bars · 2026-09-30T07:16:28.538759+00:00
  4. Financial Modeling Prep analyst price-target consensus and quote snapshot · 2026-09-30T07:16:28.535967+00:00

Methodology

Reported and consensus figures come from FN2's earnings event records. Market reaction and volume are calculated from daily adjusted bars around the event; abnormal move subtracts the SPY move over the same window.

Analyst target low, average, and high values are derived at request time from each named analyst's latest persisted FMP target. The current-price marker comes from FN2's persisted market snapshot. They are sell-side estimates, not an FN2 valuation or recommendation.

Transcript intelligence is a structured synthesis of the current and prior earnings-call analyses. Missing values stay missing and are never estimated.

By FN2 Research · Updated · As of 2026-09-30. For educational purposes only; not investment advice.