Kymera Therapeutics, Inc. · KYMR · FY2026 Q2 · Calendar Q3 2026

Kymera advances KT-621 while broadening its immunology pipeline

The current analysis supports a constructive but conditional view: rapid KT-621 execution, pipeline diversification, partnership milestones and financial runway strengthen Kymera's development position, while clinical, competitive and regulatory risks remain material.

Reported Before market openNASDAQHealthcare $10.53B market cap
100quality score

Earnings scorecard

Reported versus consensus
Reported EPS $-0.62 Consensus $-0.71
EPS surprise +13.0% Reported versus consensus
Reported revenue $65.0M Consensus $32.8M
Revenue surprise +98.3% Reported versus consensus

Market reaction

prior-close to event-session close
Stock move +1.0% Event window
SPY move -0.2% Same window
Abnormal move +1.2% Stock minus SPY
Volume 1.0× Versus trailing sessions
Subsequent drift +12.5% Up to 20 sessions
KYMRSPY benchmark

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Transcript intelligence

What changed

Compared with the prior analysis, KT-621 AD enrollment finished six months early, moving top-line data to year-end 2026 and Phase III to mid-2027. KT-579 and Sanofi's KT-485 also progressed.

Guidance delta

Guidance sentiment remained maintained; no change was identified in the supplied analysis.

Key takeaways

  • KT-621 atopic-dermatitis Phase 2b enrollment finished six months early, with top-line data expected by year-end 2026.
  • KT-579 is slated for a Q4 2026 healthy-volunteer readout, while Sanofi's KT-485 program reached Phase I and generated a milestone.
  • Approximately $1.5 billion in cash and investments supports a runway into 2029, according to the analysis.

Management priorities

  • Advance KT-621 toward Phase III in atopic dermatitis and asthma.
  • Move KT-579 toward a lupus patient study after the healthy-volunteer readout.
  • Build commercial capabilities and continue advancing diversified degrader programs.

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Earnings History

Estimate Beat Miss Match
KYMR EPS earnings history estimate and actual scatter chart 10 reported fiscal quarters and 4 future estimate-only quarters. Q2 '24 estimate $-0.69 Q2 '24 actual $-0.58, beat Q3 '24 estimate $-0.83 Q3 '24 actual $-0.82, match Q2 '25 estimate $-0.83 Q2 '25 actual $-0.95, miss Q3 '25 estimate $-0.71 Q3 '25 actual $-0.90, miss Q4 '25 estimate $-0.78 Q4 '25 actual $-0.97, miss Q1 '26 estimate $-0.89 Q1 '26 actual $-0.71, beat Q2 '26 estimate $-0.71 Q2 '26 actual $-0.62, beat Q3 '26 estimate $-1.26 Q3 '26 actual $-1.32, miss Q4 '26 estimate $-1.29 Q1 '27 estimate $-1.35 Q2 '27 estimate $-1.43 Q3 '27 estimate $-1.40
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Analyst Consensus ?

ConsensusBuy27 ratings
Bullish2488.9%
Neutral311.1%
Bearish00.0%

Analyst 52W Price Targets

$126.63Current
$32Low
$109.4Average
$180High

Latest persisted target per named analyst; persisted current price from FN2's market snapshot as of Oct 31, 2026. Not an FN2 forecast.

Firm-level rating actions

FMP grade actions identify the grading firm, not a named analyst.

FirmRatingPrior ratingActionDate
Truist Securities Buy BuyMaintainOct 30, 2026
RBC Capital Sector Perform Sector PerformMaintainOct 30, 2026
BTIG Buy BuyMaintainOct 29, 2026
Morgan Stanley Overweight OverweightMaintainOct 27, 2026
Citigroup Buy BuyMaintainOct 5, 2026
Stifel Buy BuyMaintainSep 22, 2026
B of A Securities Buy BuyMaintainSep 14, 2026
Wolfe Research Outperform Peer PerformUpgradeSep 10, 2026
Guggenheim Buy BuyMaintainAug 31, 2026
Wells Fargo Overweight OverweightMaintainAug 27, 2026
Barclays Overweight OverweightMaintainAug 6, 2026
Mizuho Outperform OutperformMaintainJul 16, 2026
B. Riley Securities Buy BuyMaintainJun 29, 2026
Canaccord Genuity Buy BuyMaintainJun 26, 2026
UBS Buy BuyMaintainMar 3, 2026
Stephens & Co. Overweight OverweightMaintainMar 2, 2026
Piper Sandler Overweight OverweightMaintainFeb 26, 2026
JP Morgan Overweight OverweightMaintainDec 10, 2025
Oppenheimer Outperform OutperformMaintainDec 9, 2025
Leerink Partners Outperform OutperformMaintainDec 9, 2025
Jefferies Buy BuyMaintainDec 9, 2025
HC Wainwright & Co. Buy BuyMaintainDec 9, 2025
Credit Suisse Neutral NeutralMaintainAug 4, 2023
Raymond James Outperform Market PerformUpgradeMay 5, 2023
Goldman Sachs Buy BuyMaintainDec 16, 2022
SVB Leerink Market Perform Market PerformMaintainDec 15, 2022
Berenberg Buy BuyMaintainApr 14, 2021
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Named analyst price targets

Upside is calculated against the persisted current price $126.63. FMP does not supply a rating on these named-analyst rows.

FirmAnalyst52W targetPrice when postedUpsideDate
OppenheimerJeff Jones$140$122.6 +10.6%Oct 29, 2026
Loop Capital MarketsLeah Rush Cann$132$121.52 +4.2%Oct 29, 2026
Raymond JamesThomas Deal$140$109.3 +10.6%Oct 8, 2026
Piper SandlerBiren Amin$140$119.9 +10.6%Sep 23, 2026
Stifel NicolausAnalyst unavailable$152$117.67 +20.0%Sep 22, 2026
Wolfe ResearchAnalyst unavailable$180$115.43 +42.1%Sep 10, 2026
GuggenheimBrad Canino$170$118.15 +34.2%Aug 31, 2026
Morgan StanleyJudah Frommer$135$104.96 +6.6%Aug 6, 2026
BarclaysAnalyst unavailable$139$105.48 +9.8%Aug 6, 2026
OppenheimerJeff Jones$125$105.48 -1.3%Aug 5, 2026
Deutsche BankDavid Hoang$120$105.25 -5.2%Jul 30, 2026
GuggenheimAnalyst unavailable$135$110.05 +6.6%Jul 28, 2026
Mizuho SecuritiesJoseph Catanzaro$140$114.12 +10.6%Jul 16, 2026
RBC CapitalBrian Abrahams$115$119.35 -9.2%Jul 13, 2026
Truist FinancialSrikripa Devarakonda$136$108.12 +7.4%Jun 29, 2026
Canaccord GenuityEdward Nash$129$116.46 +1.9%Jun 26, 2026
B.Riley FinancialKalpit Patel$155$116.46 +22.4%Jun 26, 2026
Loop Capital MarketsLeah Rush Cann$97$73.95 -23.4%Jun 8, 2026
Canaccord GenuityEdward Nash$106$82.71 -16.3%May 6, 2026
Morgan StanleyJudah Frommer$119$80.73 -6.0%Apr 30, 2026
Morgan StanleyJudah Frommer$123$95.03 -2.9%Feb 26, 2026
RBC CapitalBrian Abrahams$108$91.87 -14.7%Feb 26, 2026
BarclaysEliana Merle$133$72.15 +5.0%Jan 27, 2026
RBC CapitalAnalyst unavailable$103$85.62 -18.7%Dec 16, 2025
StephensSudan Loganathan$110$89.9 -13.1%Dec 11, 2025
Mizuho SecuritiesAnalyst unavailable$120$89.9 -5.2%Dec 11, 2025
JefferiesAnalyst unavailable$122$86.82 -3.7%Dec 9, 2025
Truist FinancialSrikripa Devarakonda$116$86.27 -8.4%Dec 9, 2025
H.C. WainwrightAndrew Fein$134$86.87 +5.8%Dec 9, 2025
OppenheimerAnalyst unavailable$120$85.6 -5.2%Dec 9, 2025
Morgan StanleyAnalyst unavailable$127$87.21 +0.3%Dec 9, 2025
Piper SandlerAnalyst unavailable$125$94.3 -1.3%Dec 9, 2025
Wells FargoDerek Archila$116$94.3 -8.4%Dec 9, 2025
BarclaysAnalyst unavailable$119$94.3 -6.0%Dec 9, 2025
Leerink PartnersAnalyst unavailable$118$94.3 -6.8%Dec 8, 2025
BTIGJeet Mukherjee$138$94.3 +9.0%Dec 8, 2025
Stifel NicolausAlex Thompson$114$93.76 -10.0%Dec 8, 2025
Truist FinancialAnalyst unavailable$80$67.3 -36.8%Nov 26, 2025
UBSAnalyst unavailable$90$66.04 -28.9%Nov 26, 2025
H.C. WainwrightAnalyst unavailable$84$59.91 -33.7%Nov 5, 2025
BarclaysAnalyst unavailable$70$59.91 -44.7%Nov 5, 2025
Morgan StanleyAnalyst unavailable$73$59.91 -42.4%Nov 4, 2025
JefferiesAnalyst unavailable$73$61.06 -42.4%Nov 4, 2025
OppenheimerJeff Jones$67$59.91 -47.1%Nov 4, 2025
GuggenheimBrad Canino$90$61.84 -28.9%Nov 3, 2025
BTIGJeet Mukherjee$75$58.32 -40.8%Oct 22, 2025
OppenheimerAnalyst unavailable$63$56.6 -50.2%Oct 1, 2025
Truist FinancialAnalyst unavailable$68$58.93 -46.3%Sep 30, 2025
H.C. WainwrightAnalyst unavailable$70$50.87 -44.7%Sep 18, 2025
BarclaysAnalyst unavailable$60$48.78 -52.6%Sep 16, 2025
RBC CapitalBrian Abrahams$70$48.26 -44.7%Sep 16, 2025
OppenheimerJeff Jones$53$44.12 -58.1%Jun 27, 2025
BTIGJeet Mukherjee$59$46.47 -53.4%Jun 26, 2025
JefferiesKelly Shi$64$46.21 -49.5%Jun 25, 2025
GuggenheimMichael Schmidt$60$43.58 -52.6%Jun 3, 2025
H.C. WainwrightAnalyst unavailable$54$31.35 -57.4%Feb 28, 2025
BMO CapitalEtzer Darout$55$44.08 -56.6%Dec 5, 2024
Wells FargoDerek Archila$57$48.54 -55.0%Dec 2, 2024
OppenheimerJeff Jones$56$49.47 -55.8%Sep 27, 2024
Wolfe ResearchAndy Chen$65$47.78 -48.7%Aug 26, 2024
H.C. WainwrightAndrew Fein$60$40.31 -52.6%Aug 8, 2024
H.C. WainwrightAndrew Fein$46$32.29 -63.7%Jun 17, 2024
Piper SandlerEdward Tenthoff$56$34.84 -55.8%May 23, 2024
OppenheimerJeff Jones$52$36.3 -58.9%May 3, 2024
Wells FargoAnalyst unavailable$42$24.71 -66.8%Jan 3, 2023
Morgan StanleyAnalyst unavailable$41$27.05 -67.6%Dec 19, 2022
Goldman SachsAnalyst unavailable$52$28.26 -58.9%Dec 16, 2022
Leerink PartnersAnalyst unavailable$31$29.62 -75.5%Dec 15, 2022
Morgan StanleyMichael Turits$45.2$29.11 -64.3%Dec 6, 2022
Credit SuisseRichard Law$32$29.11 -74.7%Dec 6, 2022
Morgan StanleyAnalyst unavailable$37$31.81 -70.8%Aug 29, 2022
Credit SuisseAnalyst unavailable$61$32.83 -51.8%Aug 10, 2022
Morgan StanleyAnalyst unavailable$35$21 -72.4%May 4, 2022
Credit SuisseAnalyst unavailable$60$21.26 -52.6%May 4, 2022
UBSEliana Merle$80$43.2 -36.8%May 20, 2021
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Company context

Snapshot as of publication

Kymera Therapeutics, Inc. is a biopharmaceutical company dedicated to discovering and developing pioneering small molecule therapeutics. These treatments operate by harnessing the body's inherent protein degradation system to selectively eliminate disease-causing proteins. The company's pipeline features several programs, including the IRAK4 program, currently in Phase I clinical trials, which targets various immunology-inflammation disorders such as hidradenitis suppurativa, atopic dermatitis, macrophage activation syndrome, generalized pustular psoriasis, and rheumatoid arthritis. Additionally, Kymera is advancing its IRAKIMiD program, designed to address MYD88-mutated diffuse large B cell lymphoma. Other key programs include the STAT3 program, focused on hematological malignancies, solid tumors, autoimmune diseases, and fibrosis, as well as the MDM2 program, which is also aimed at hematological malignancies and solid tumors. The company was founded in 2015 and maintains its headquarters in Watertown, Massachusetts.

Historical context

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Sources

  1. Earnings call transcript and parsed analysis · 2026-08-05T20:09:17.545388+00:00
  2. FN2 earnings calendar · 2026-09-10T01:23:13.706414+00:00
  3. Polygon adjusted daily market bars · 2026-10-31T05:00:40.637802+00:00
  4. Financial Modeling Prep analyst price-target consensus and quote snapshot · 2026-10-31T05:00:40.635018+00:00

Methodology

Reported and consensus figures come from FN2's earnings event records. Market reaction and volume are calculated from daily adjusted bars around the event; abnormal move subtracts the SPY move over the same window.

Analyst target low, average, and high values are derived at request time from each named analyst's latest persisted FMP target. The current-price marker comes from FN2's persisted market snapshot. They are sell-side estimates, not an FN2 valuation or recommendation.

Transcript intelligence is a structured synthesis of the current and prior earnings-call analyses. Missing values stay missing and are never estimated.

By FN2 Research · Updated · As of 2026-10-31. For educational purposes only; not investment advice.